High-purity Folic acid 59-30-3

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Shanghai and Hangzhou or as you advise
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Overview
Quick Details
CAS No.:
59-30-3
Other Names:
PGA;Folan;folic
MF:
C19H19N7O6
EINECS No.:
200-419-0
Place of Origin:
Zhejiang, China (Mainland)
Type:
Auxiliaries and Other Medicinal Chemicals, Vitamins, Amino Acids and Coenzymes, Feed additives
Grade Standard:
Feed Grade, Food Grade, Medicine Grade, Tech Grade, Other
Brand Name:
HZPH
Model Number:
API
Purity:
98.00%
CAS:
59-30-3
Melting Point:
250 °C
Water Solubility ::
1.6mg/L(25℃)
WGK Germany:
1
Chemical Properties:
orange to yellow crystalline powder
Usage:
Anti-anemia drug
Packaging & Delivery
Packaging Details
As you advise
Delivery Time
Within 1 week
[Appearance]
Yellow to orange yellow crystals or crystalline powder.
[Density]
1.68 g/cm3
[Melting Point]
250℃
[Alpha]
20° (C=1, 0.1N NAOH)
[Water]
1.6 mg/L (25℃)
[Solubilities]
Water Solubility, 1.6 mg/L (25°C)
[Color/Form]
Yellowish-orange crystals; extremely thin platelets (elongated @ 2 ends) from hot water
[Stability]
Stable. Incompatible with heavy metal ions, strong oxidizing agents, strong reducing agents. Solutions may be light and heat sensitive.
[Storage temp]
2-8°C
[Spectral properties]
Specific optical rotation: +23 deg at 25 deg C/D (c= 0.5 in 0.1 N sodium hyroxide)
UV max (pH 13): 256, 283, 368 nm (log E 4.43, 4.40, 3.96)
MASS: 76456 44 (NIST/EPA/MSDC Mass Specral Database 1990 Version)
IR: 5025 (Coblentz Society Spectral Collection)
UV: 2-601 (Organic Electronic Spectral Data, Phillips et al, John Wiley & Sons, New York)
[Computed Properties]
Molecular Weight:441.39746 [g/mol]
Molecular Formula:C19H19N7O6
XLogP3-AA:-1.1
H-Bond Donor:6
H-Bond Acceptor:9
Rotatable Bond Count:9
Tautomer Count:60
Exact Mass:441.139681
MonoIsotopic Mass:441.139681
Topological Polar Surface Area:209
Heavy Atom Count:32
Formal Charge:0
Complexity:767
Isotope Atom Count:0
Defined Atom Stereocenter Count:1
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Acceptor Count:7
Feature 3D Donor Count:5
Feature 3D Anion Count:2
Feature 3D Cation Count:2
Feature 3D Ring Count:3
Effective Rotor Count:10
Conformer Sampling RMSD:1
CID Conformer Count:60

Safety and Handling

[Hazard Codes]
Xn
[Risk Statements]
R33;R62;R68
[Safety Statements ]
S24/25
[Safety]

Risk Statements: 33-62-68
R33: Danger of cumulative effects.
R62: Risk of impaired fertility.
R68: Possible risk of irreversible effects.
Safety Statements: 24/25
S24/25: Avoid contact with skin and eyes.
WGK Germany: 1
RTECS: LP5425000
F: 8

[Formulations/Preparations]
5 mg (base) per mL (Rx) [Folvite (benzyl alcohol 1.5 %)]; 10 mg per mL (Rx)
Folic acid (FOLVITE) is marketed as oral tablets containing 0.4, 0.8, and 1 mg and as an aqueous solution for injection. Tablets of folic acid contain either 0.1, 0.4, 0.8, or 1 mg of pteroylglutamic acid, as an aqueous solution for injection, and in combination with other vitamins and minerals
Injectable solutions are prepared by dissolving folic acid in normal sodium bicarbonate solution (which should be sterilized by filtration) or by preparing solutions of the sodium or methylglucamine salt.
Lexpec Folic Acid. Syrup containing folic acid 2.5 mg in each 5 mL (recommended diluent, Sorbitol Solution or Sorbitol Solution and water, equal parts).
10% feed grade, USP
[Exposure Standards and Regulations]
Folic acid (CAS Reg. No. 59-30-3), also known as folacin or folate, may be safely used in food as a nutrient in accordance with the following prescribed conditions: (a) Folic acid is the chemical N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid. (b) Folic acid meets the specifications of the Food Chemicals Codex, 4th ed. (1996), pp. 157?158, which is incorporated by reference in accordance with 5 U.S.C. 552(a) and 1 CFR part 51. (c) Folic acid may be added to foods subject to a standard of identity established under section 401 of the Federal Food, Drug, and Cosmetic Act (the act) when the standard of identity specifically provides for the addition of folic acid. (d) Folic acid may be added, at levels not to exceed 400 micrograms (g) per serving, to breakfast cereals, as defined under 170.3(n)(4) of this chapter, and to corn grits at a level such that each pound of corn grits contains not more than 1.0 milligram of folic acid. (e) Folic acid may be added to infant formula in accordance with section 412(i)(1) of the act or with regulations issued under section 412(i)(2) of the act which are codified in ?107.100 of this chapter. (f) Folic acid may be added to a medical food, as defined in section 5(b)(3) of the Orphan Drug Act (21 U.S.C. 360ee(b)(3)), at levels not to exceed the amount necessary to meet the distinctive nutritional requirements of the disease or condition for which the food is formulated. (g) Folic acid may be added to food for special dietary use at levels not to exceed the amount necessary to meet the special dietary needs for which the food is formulated. (h) Folic acid may be added to foods represented as meal-replacement products, in amounts not to exceed: (1) Four hundred per serving if the food is a meal-replacement that is represented for use once per day; or (2) Two hundred per serving if the food is a meal-replacement that is represented for use more than once per day.
Drug products containing certain active ingredients offered over-the-counter (OTC) for certain uses. A number of active ingredients have been present in OTC drug products for various uses, as described below. However, based on evidence currently available, there are inadequate data to establish general recognition of the safety and effectiveness of these ingredients for the specified uses: Folic acid is included in weight control drug products.
[Reactivities and Incompatibilities]
Folic acid is incompatible with oxidizing and reducing agents and with heavy metal ions.
[Specification]

Folic acid , with CAS number of 59-30-3, can be called Pteroyl-l-glutamic acid ; pteroylmonoglutamic acid ; pteroylglutamic acid ; pteroyglutamic acid ; pteglu ; pga ; n-[4-[[(2-amino-4-hydroxy-6-pteridyl)methyl]amino]benzoyl]glutamic acid ; n-4-[(2-amido-4-oxo-1,4-dihydro-6-terene)methylamino]benzoyl-l-glutamic acid . Folic Acid (CAS NO.59-30-3) is a toxic substance, with flammability, burning will produce toxic gases, so it should be stored in a tightly closed container which is cool, dry and well-ventilated, be away from incompatible substances and light. Dry powder, foam, sand, carbon dioxide, water mist can be used if something urgent happened.

[Octanol/Water Partition Coefficient]
log Kow = -2.81 /Estimated/
[Disposal Methods]

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Use and Manufacturing

[Use and Manufacturing]
Methods of Manufacturing
Condensation of 2,5,6-triamino-4(3H)-pyrimidinone, p-aminobenzoyl-L-glutamic acid, and 2,3-dibromopropanal.
Synthetic pteroylglutamic acid is made by the reaction of 2,3-di-bromopropanol,2,4,5-triamino-6-hydroxypyrimidine and para-aminobenzoyl glutamic acid

U.S. Imports
(1983) 5.07X10+7 g
[Usage]
Medication.